Strategic Objectives
• Master the selection of chemical linkers for any nanostructure.
• Minimize non-specific protein adsorption and immune clearance.
• Optimize ligand density for maximum therapeutic efficacy.
• Bridge the gap between material science and molecular biology.
The Core Challenge
While core synthesis is well-documented, the 'black box' of surface chemistry often leads to failed stability and poor biological targeting.
01
The Interface of Life and Matter
02
Foundations of Bioconjugation
03
The Gold Standard
04
Silane Coupling Agents
05
Polymer Brushes
06
The Power of PEGylation
07
EDC/NHS Coupling
08
Click Chemistry
09
Maleimide and Sulfhydryl Targeting
10
The Avidin-Biotin System
11
Characterizing the Surface
12
Measuring Zeta Potential
13
The Protein Corona
14
Linker Length and Flexibility
15
Bioorthogonal Chemistry
16
Surface Plasma Treatment
17
Enzymatic Surface Modification
18
Targeting Moieties
19
Cleavable Linkers
20
Nanotoxicology and the Surface
21
Translational Surface Chemistry
Explore Research Ecosystem
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